Explainable AI for earlier detection of brain diseases

Artur Chudzik, PhD

Artur Chudzik

Can subtle patterns in cognition, gait, facial expression, eye movements, and brain imaging reveal Parkinson's and Alzheimer's disease before symptoms become obvious? Earlier detection matters because visible symptoms often appear after years of underlying damage. By the time routine assessment can see the disease clearly, critical brain cells may already be lost. Finding signals sooner supports monitoring, treatment decisions, and interventions that can alter the disease trajectory.

Artur Chudzik

About

Artur Chudzik is an AI engineer and researcher building explainable AI for earlier detection of Parkinson's and Alzheimer's disease. His work turns subtle patterns in cognition, gait, facial expression, eye movements, and brain imaging into interpretable digital biomarkers for monitoring disease and guiding treatment decisions. He holds a PhD in Computer Science from the Polish-Japanese Academy of Information Technology and is a member of the Digital Biomarkers in Neurodegenerative Diseases research group. He also has more than a decade of experience in software engineering and applied AI, which helps him turn research ideas into reliable, transparent, and practical systems.

My work asks a simple question: can we detect neurodegenerative disease earlier by learning from subtle patterns in behavior, cognition, and the brain?

Neurodegenerative diseases are brain diseases in which nerve cells gradually lose function and die. Timing matters because visible motor symptoms in Parkinson's disease often appear only after many dopamine-producing neurons in the substantia nigra are already dead. In Alzheimer's disease, damaging brain changes can begin decades before dementia is diagnosed. The disease process can be underway while the evidence still looks incomplete, ambiguous, or too late to act on confidently. Earlier signals can help clinicians monitor risk, choose interventions, and adjust treatment before the disease trajectory becomes harder to change.

The methodological challenge is not only to classify disease, but to make the evidence behind a prediction understandable. That is why this work combines brain imaging, online cognitive testing, eye tracking, movement analysis, facial expression analysis, and other digital biomarkers with interpretable machine-learning methods.

Research focus

Detect subtle signals

What changes before the disease becomes clinically obvious? Cognitive, gait, imaging, eye-movement, and facial-expression patterns may carry early signs of neurological change.

Build interpretable models

A prediction is not sufficient if nobody can understand why it was made. Models need to be transparent enough for researchers and clinicians to inspect, challenge, and understand.

Connect patterns to disease

Digital biomarkers matter when they connect measurement to mechanism: what can a signal say about Parkinson's disease, Alzheimer's disease, and related disorders?

Selected publications

These papers address one central gap: brain disease datasets need computational methods that are intelligent, dependable, explainable, and validated on complex real-world signals. The recurring question is how subtle biomedical data can become interpretable evidence for earlier detection and monitoring of neurodegenerative disease.

Featured

Machine Learning and Digital Biomarkers Can Detect Early Stages of Neurodegenerative Diseases

Reviews how online cognitive tests, eye tracking, movement data, and other digital biomarkers can support AI-based detection of early Parkinson's and Alzheimer's disease.

Machine Learning Recognizes Stages of Parkinson's Disease Using Magnetic Resonance Imaging

Uses T1 MRI scans and interpretable machine-learning features based on brain-region volumes and spatial relationships to distinguish healthy controls, prodromal cases, and Parkinson's disease.

Machine Learning and Eye Movements Give Insights into Neurodegenerative Disease Mechanisms

Shows how eye-movement tasks can be analyzed with machine learning to better understand Parkinson's and Alzheimer's disease mechanisms.

Digital testing

Classification of Parkinson's Disease Using Machine Learning with MoCA Response Dynamics

Shows that response-time dynamics from online MoCA testing can improve machine-learning classification of Parkinson's disease versus healthy controls.

Recognizing Patterns of Parkinson's Disease Using Online Trail Making Test and Response Dynamics

Uses an online Trail Making Test to show how timing-based measures can capture cognitive and motor changes linked to Parkinson's disease severity.

Investigating the Impact of Parkinson's Disease on Brain Computations

Compares healthy controls and Parkinson's patients with online neuropsychological tasks to identify subtle cognitive and behavioral changes.

Disease modeling

Machine Learning Methods for Parkinson's Disease Datasets

Synthesizes machine-learning approaches for Parkinson's disease datasets, including diffusion tensor imaging, eye tracking, and online cognitive testing.

How to Cure Alzheimer's Disease

Argues that Alzheimer's prevention requires finding the beginning of neurodegeneration decades before symptoms become clinically visible.

Mechanisms and imaging

Eye-Tracking and Machine Learning Significance in Parkinson's Disease Symptoms Prediction

Combines eye-tracking and neuropsychological testing to predict symptom progression in Parkinson's disease.

Comparison of Different Data Mining Methods to Determine Disease Progression in Dissimilar Groups of Parkinson's Patients

Compares rough-set models and other data-mining methods for predicting Parkinson's disease progression across patient groups.

DTI Helps to Predict Parkinson's Patient's Symptoms Using Data Mining Techniques

Uses diffusion tensor imaging and data mining to estimate symptom development after deep brain stimulation.

In press

Symbolic AI for Parkinson's Disease Severity Classification / LNCS, in press

Uses MRI-derived spatial biomarkers in a rule-based model for transparent Parkinson's disease severity classification.

How Can AI Help to Prevent Dementia / LNCS, in press

Studies early dementia risk with explainable AI, cognitive test results, and genetic markers.

Preliminary Analysis of Nonlinear Stability in Human Gait / LNCS, in press

Studies marker-based gait stability with nonlinear dynamics as a possible screening signal for neurodegenerative disease.

Theoretical physics and cosmology

Questions about the brain eventually lead to questions about consciousness, time, and the physical structure that makes experience possible. What is time? Why does it seem to have a direction? What is space, what was the beginning of the universe, and why is there anything at all? This theoretical work uses computation to turn such questions into models that can be tested against measurable structure.

Revisiting the Relationship Between the Scale Factor (a(t)) and Cosmic Time (t) Using Numerical Analysis

Asks whether the cosmological constant is necessary, testing a simpler relationship between cosmic time and expansion against large-scale observations.

Profiles and contact

Publications, code, academic profiles, and contact links are collected below.