Explainable AI for earlier detection of brain diseases
Can subtle patterns in cognition, gait, facial expression, eye movements, and brain imaging reveal Parkinson's and Alzheimer's disease before symptoms become obvious? Earlier detection matters because visible symptoms often appear after years of underlying damage. By the time routine assessment can see the disease clearly, critical brain cells may already be lost. Finding signals sooner supports monitoring, treatment decisions, and interventions that can alter the disease trajectory.
Artur Chudzik is an AI engineer and researcher building explainable AI for earlier detection of Parkinson's and Alzheimer's disease. His work turns subtle patterns in cognition, gait, facial expression, eye movements, and brain imaging into interpretable digital biomarkers for monitoring disease and guiding treatment decisions. He holds a PhD in Computer Science from the Polish-Japanese Academy of Information Technology and is a member of the Digital Biomarkers in Neurodegenerative Diseases research group. He also has more than a decade of experience in software engineering and applied AI, which helps him turn research ideas into reliable, transparent, and practical systems.
My work asks a simple question: can we detect neurodegenerative disease earlier by learning from subtle patterns in behavior, cognition, and the brain?
Neurodegenerative diseases are brain diseases in which nerve cells gradually lose function and die. Timing matters because visible motor symptoms in Parkinson's disease often appear only after many dopamine-producing neurons in the substantia nigra are already dead. In Alzheimer's disease, damaging brain changes can begin decades before dementia is diagnosed. The disease process can be underway while the evidence still looks incomplete, ambiguous, or too late to act on confidently. Earlier signals can help clinicians monitor risk, choose interventions, and adjust treatment before the disease trajectory becomes harder to change.
The methodological challenge is not only to classify disease, but to make the evidence behind a prediction understandable. That is why this work combines brain imaging, online cognitive testing, eye tracking, movement analysis, facial expression analysis, and other digital biomarkers with interpretable machine-learning methods.
What changes before the disease becomes clinically obvious? Cognitive, gait, imaging, eye-movement, and facial-expression patterns may carry early signs of neurological change.
A prediction is not sufficient if nobody can understand why it was made. Models need to be transparent enough for researchers and clinicians to inspect, challenge, and understand.
Digital biomarkers matter when they connect measurement to mechanism: what can a signal say about Parkinson's disease, Alzheimer's disease, and related disorders?
These papers address one central gap: brain disease datasets need computational methods that are intelligent, dependable, explainable, and validated on complex real-world signals. The recurring question is how subtle biomedical data can become interpretable evidence for earlier detection and monitoring of neurodegenerative disease.
Reviews how online cognitive tests, eye tracking, movement data, and other digital biomarkers can support AI-based detection of early Parkinson's and Alzheimer's disease.
Uses T1 MRI scans and interpretable machine-learning features based on brain-region volumes and spatial relationships to distinguish healthy controls, prodromal cases, and Parkinson's disease.
Shows how eye-movement tasks can be analyzed with machine learning to better understand Parkinson's and Alzheimer's disease mechanisms.
Shows that response-time dynamics from online MoCA testing can improve machine-learning classification of Parkinson's disease versus healthy controls.
Uses an online Trail Making Test to show how timing-based measures can capture cognitive and motor changes linked to Parkinson's disease severity.
Compares healthy controls and Parkinson's patients with online neuropsychological tasks to identify subtle cognitive and behavioral changes.
Synthesizes machine-learning approaches for Parkinson's disease datasets, including diffusion tensor imaging, eye tracking, and online cognitive testing.
Argues that Alzheimer's prevention requires finding the beginning of neurodegeneration decades before symptoms become clinically visible.
Combines eye-tracking and neuropsychological testing to predict symptom progression in Parkinson's disease.
Compares rough-set models and other data-mining methods for predicting Parkinson's disease progression across patient groups.
Uses diffusion tensor imaging and data mining to estimate symptom development after deep brain stimulation.
Uses MRI-derived spatial biomarkers in a rule-based model for transparent Parkinson's disease severity classification.
Studies early dementia risk with explainable AI, cognitive test results, and genetic markers.
Studies marker-based gait stability with nonlinear dynamics as a possible screening signal for neurodegenerative disease.
Questions about the brain eventually lead to questions about consciousness, time, and the physical structure that makes experience possible. What is time? Why does it seem to have a direction? What is space, what was the beginning of the universe, and why is there anything at all? This theoretical work uses computation to turn such questions into models that can be tested against measurable structure.
Asks whether the cosmological constant is necessary, testing a simpler relationship between cosmic time and expansion against large-scale observations.
Publications, code, academic profiles, and contact links are collected below.